what do pargyline and clorgyline stop being break down?
monoamines such as adrenaline + serotonin (neurotransmitters)
14 of 33
why could pargyline+clorgyline be useful in treating depression?
blocks the enxzyme that breaks down transmitters concentration of transmitters stays high for longer
15 of 33
what is captopril used to treat?
hypertension and some types of congestive heart failure
16 of 33
what is captopril?
an angiotensin-converting enzyme inhibitor
17 of 33
what is acetylsalicic acids other name?
aspirin
18 of 33
what does aspirin do?
Aspirin inhibits cyclooxygenate enzyme which produce lipid mediators, messengers and signal mediators, when inhibited no more inflammatory response brings down swelling, pain and fever
19 of 33
what does angiotensin 2 do?
vasoconstrictor, releases aldesterone (more uptake of salt + water from kidneys -> high bp) from adrenal cortex, constricts blood vessels
20 of 33
what do ACE inhibitors do?
stop angiotensin converting enzyme so less angiotensin 2, not as much water + salt uptake, less constriction
21 of 33
why are ACE inhibitors used to prevent blood clots?
angiotensin 2 inhibits tissue plasminogen activator so plasminogen--> plasmin does not happen, plasmin dissolves blood clots
22 of 33
whatare 2 drugs that target transporters?
fluoxetine and digoxin
23 of 33
how does fluoxetine (prozac) work?
by inhibiting serotin reuptake, targets serotionin transporters in the brain, stops transporter from working so serotonin work at rec longer
24 of 33
why is fluoxetine more favoured than MAO inhibitors such as paragyline+clorgyline to treat depression?
less side effects and more specific in action
25 of 33
where is digoxin found?
foxglove flowers
26 of 33
what does digoxin target?
sodium/potassium transporter ATPase in the heart
27 of 33
how does digoxin work?
stops Na/K ATPase in heart, sodium builds up in heart cells, knock on effect as another transporter swaps sodium for calcium, build up of Ca in heart cells = more contractions
28 of 33
what is digoxin used to treat? what effect does it have on the heart?
heart failure and fibrillation as slows down heart rate
29 of 33
how many proteins in the human genome did they find that we can target?
600-1500
30 of 33
examples of opiates?
heroin and morphine
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examples of drugs that bind to muscarinic receptors?
pilocarpine, atropine
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examples of drugs that bind to nicotinic receptors?
nicotine, curare
33 of 33
Other cards in this set
Card 2
Front
what is atropine?
Back
a muscarinic receptor antagonist prevents pilocarpine from working
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