Cannabis researchers

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  • Created by: freya_bc
  • Created on: 24-04-17 14:09
Black et al., (1998)
increased high with 15s breath hold vs 7s- not signif though as after peak THC levels reached, concn falls through metabolism
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Devane et al., (1988)
ID'd the cannabinoid receptor- receptors active in areas consistent with behavioural effects e.g. hippocampus- spatial memory
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Iversen (2000)
behavioural effects- the buzz, the high, stoned, flashbacks at high doses
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Foltin et al., (1988)
increased hunger shown in humans after cannabis intake
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Williams and Kirkham (2002)
also found this effect in rats- palatability increases in rats following 9THC administration, but these effects abolished by CB1 antagonists
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Huestis et al., (2001)
given 2.64% THC joint some given SR141716 others placebo, less self report of feeling high and stoned in antagonist group and lower HR effects not abolished however because still perceive effects when having antagonist so need more anta or CB1 ...
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cont
...CB1 receptors mediate effects elsewhere too
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Agurell et al., (1986)
route of administration has substantial effect on time course- oral peaks at similar sort of level to smoking but takes longer to get to that point
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Kirk and coworkers (1998)
THC or placebo, informed vs not, informed gave higher ratings, expectation of consuming cannabinoids enhanced pleasurable effects but more positive reaction when given placebo instead, THC peak more rapidly
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Curran et al., (2002)
effects of THC oral dose on verbal memory- 7.5mg worse than baseline at 2hours but about same as b after 6, 15mg markedly worse after 2hours still bad after 6 - more disruption, effect attenuated in LT users tolerance
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Ramaekers et al., (2004)
risk factor in car accidents- tasks demands are high so cannabis will disrupt your abilities
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Richardson et al., (1988)
SR 141716 induces hyperalgesia/increased pain sensitivity, endocannabinoids reduce responsiveness to pain, analgesia effect
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Black (2004)
SR141716 reduces food consumption in rats and humans, endocannabinoids role in reg and control in appetite and hunger
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Varvel and Lichtman (2002)
cb1 knockout mice show normal acquisition of spatial learning- morris water maze, if wild type cannot reverse what already learned when platform moved- look in approp places, go to original, decrease hippocampal synaptic transmission interferes...
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cont
...with LT potentiation (important form of synaptic plasticity underlying some forms of learning)
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Marscicano et al., (2002)
CB1 knockout show normal fear conditioning- impaired extinction: a deficit in unlearning/new learning
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Ledent et al., (1999), Zimmer et al., (1999)
most behavioural effects of tHC abolished by CB1 receptor knockout mice t/f effect mediated by CB1 receptor activation
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Varvel and Lichtman (2002)
rats first trained to lever press for IV cocaine, extign, then lever press assoc with IV THC, dose equiv to single joint effect abolished wit cb1 anta, low level response to saline, THC increase when remove THC press lever to try and get again...
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cont
...vehicle anta mean effect no longer shown
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Valjent and Maldonado (2000)
conditioned place preference for THC mice- only if preexposed to THC in home cages
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Justinova et al., (2003)
squirrel monkeys reliably self admin THC
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Tanda et al., (1997)
conditioned place preference produced by a low dose of THC was abolished in mutant mice lacking k-opioid receptor anta naloxazine directly in VTA of rars blocked by heroin induced DA released but also THC
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Brooks et al., (1999)
longitudinal study of 776 ** from NY, progre**ion from initial to regular user but difficult to estab if gateway to harder drugs because some people are more disposed to harder drugs
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Gruber and Pope (2002)
risk factors- family disturbances, drug use by family/peers, school performance, age of onset
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Crompton et al., (1990)
tolerance observed following repeated administration of marijuana or pure THC
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Kirk and de Wit (1999) and Lindgren et al, (1981)
same high in light/infrequent users to relative to heavy/frequent users
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Breivogel et al., (1999)
rats daily injections 10mg/kg THC over 3 weeks, progressive reduction of cb1 receptor density after repeat exposure to same dose, cannabis agonist receptor activity- some areas total desen 3w- tol
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Budney et al., (2003) Kouri et al., (1999)
resemble nicotine withdrawal symptoms, worst in first 2 weeks- can last for our a month - protracted period of time for withdrawal symptoms
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Aceto et al., (1996)
precipitated withdrawal- rats given twice daily THC injections, then SR 141716 rats displayed symptoms of hyperactivity/ consequence of stress
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De Fonseca (1997)
increase corticotrophin-releasing hormone (CRH) in precipitated withdrawal in rats
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Diana et al., (1998)
neurochemical basis for marijuana abstinence syndrome investigated using precipitated withdrawal model in cannabinoid dependent rats- decreased DA cell firing in VTA and increase corticotrophin releasing factor into centra nucleus of amyg
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Moore and Budney (2003)
significant release of cannabis treatment by CBT but consistent with what is seen for other drugs
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Haney et al., (2004)
withdrawal symptoms may be eased by oral consumption of THC, useful in ST, difficult to achieve LT abstinence
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Lynsky and Hall (2000)
link to edu performance/ more negative attitudes with school/absenteeism, amotivational syndrome but c and e not established
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Fergusson et al., (2003)
regular cannabis use early in life predicts poor school performance and drop out rates
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Solowij et al., (2002)
cog deficits in LT users- standardised tests of learning, memory and attention- LT users deficient 1 and 7 days after exposure
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Pope et al., (2001)
no difference between heavy users and controls after 28 days of exposure- cog deficits linked to recent user- reversible over time
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Cabreal and Pettit (1998)
THC supppresses immune function, increase risk of viral and bacterial infection-links to bronchitis
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Smith and Asch (1987)
reduced sperm count in men but only in heavy users
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Devane et al., (1988)

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ID'd the cannabinoid receptor- receptors active in areas consistent with behavioural effects e.g. hippocampus- spatial memory

Card 3

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Iversen (2000)

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Card 4

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Foltin et al., (1988)

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Williams and Kirkham (2002)

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Comments

Ostrigko

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Hmm, you already have a lot of plants and are looking for more seeds.

Togorotor13

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Hmm, it will be quite difficult to find investors to sell cannabis. This is a bit of a non-standard field, so that a lot of people are employed in it. Cannabis is illegal in many countries, so you risk breaking the law, as well as risking your money even in the case of a successful sale. If you plan to sell cannabis in countries where it is legalized, then the market there is already full. Are you sure that you are interested in Cannabis? I once tried to make a business for the manufacture of sarms, but people are not so willing to buy medicines, which can include cannabis. Why did you decide to change the vector of work at all, if you already have good connections with brokers and success in another field?

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