Of Mice & Men

• The bunk house guys blow their money every saturday on prostitutes and beer at "Suzy's place" - They go for some companionship but ulitimately it doesnt stop them from being lonely 
• Ranchers travel alone: The ranchers comment on how strange it is the George and Lennie are friends ("Funny how you an' him string along together")
• Crooks, the stable buck, is segregated from the others because he is black. Although he comes off as "proud" and "aloof" Crooks wants companionship. "a guy needs somebody -- to be near him.."
• Curlys wife is lonely - She's in a loveless marriage with an unfaithful husband (curley goes to the brothel with the others) Curleys wife flirts with the other ranchers for attention or appreciation
• Soledad (nearby town) - Spanish word for 'solitude' or 'loneliness'

• Lennie has no control over his destiny - he is completely reliant upon George
• Curley's wife couldn't control her destiny when she was younger and become a movie star because of "my ol' lady wouldn't let me. She cannot change her destiny now because she is married and stuck on the ranch

Destined to go wrong (says in title)

• The best laid schemes o' mice and men
  often go wrong
  and leave us nought but grief and pain
  for promised joy 

                          -  Robert Burns