Biological explanations of SZ
- Created by: lw121x
- Created on: 22-05-15 11:03
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- Biological explanations of SZ
- Genetics (twin studies)
- Kallman USA highest rate 1946 174 MZ 296 DZ 69% MZ 15% DZ
- however broad set of data misdiagnosis
- Development of bod including brain down to genetics. Inherited down
- Gottesman England 24 MZ 33DZ reared apart MZ 48% DZ 17%
- small sample + ICD biased
- genetics strong but environmental too
- Family resemblances no way of showing genetic or environmental factors
- Adoption studies
- Heston 47 children adopted bio SZ + group same foster home not SZ.
- 5 children experimental group/ none in control
- Heston 47 children adopted bio SZ + group same foster home not SZ.
- Evaluation of genetic approach:
- explanation allows SZ diagnosed early if run in family
- not 100% not full cause
- Untitled
- Kallman USA highest rate 1946 174 MZ 296 DZ 69% MZ 15% DZ
- Biochemical
- Dop hypothesis
- brain SZ patients = higher dopamine
- messages from neurons fire too easily
- dop neurons instrumental in reg attention, if disturbed cause prob with attention perception + thought = SZ
- Sz's thought to have abnormaility in the number od D2 receptors reciebing beurons = more dop binding = more neurons firing
- amphetamines = dop agonist stimulating nerve cells containing dop = synapse flooded with it = hallucinations
- rats given antagonists (antipsy drug) or agonist ie. cocaine SZ agonist. antagonists = Parkinson's
- extrapolation- no language key area SZ
- Humans EQ (emotional intelligence 7- 0.5 in rats)
- rats given antagonists (antipsy drug) or agonist ie. cocaine SZ agonist. antagonists = Parkinson's
- antipsy drug block dop
- Parkinsons = low dop = dop drug= SZ
- Evaluation
- However dop alone does not cause SZ psy factors such as expressed emotion
- = biological vulnerability
- High levels dop may be consequence rather than the cause.
- Haracz most people who showed elevated dop levels from anti psy drugs before death
- drugs that change levels of dop in brain = reduce SZ.
- Davis meta analysis effectiveness SZ Relapse 55% placebo compared to 19%
- However dop alone does not cause SZ psy factors such as expressed emotion
- brain SZ patients = higher dopamine
- Dop hypothesis
- Genetics (twin studies)
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